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Sequenceoncology

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Precision Oncology Platform

Precision Oncology.
Sequence First.

Testing as the first step, not the last resort.

Every tumor has a molecular story. Genomic profiling at diagnosis unlocks targeted therapies, predicts treatment response, and identifies hereditary cancer risk for the entire family.

Explore the Evidence Scroll

The Case for Genomic-First Oncology

Tumor profiling and germline testing should be standard-of-care at diagnosis -- not ordered after first-line therapy fails, not reserved for late-stage disease, not treated as a last resort.

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Earlier Testing, Better Outcomes

Comprehensive genomic profiling at diagnosis identifies actionable targets before treatment selection, enabling first-line precision therapy instead of empiric chemotherapy followed by molecular testing only after failure.

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Actionability Is the Norm, Not the Exception

More than half of all solid tumors harbor genomic alterations with approved or investigational targeted therapies. Delaying profiling means delaying access to the most effective treatment options available.

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Germline Findings Protect Families

Up to 10% of cancers are driven by inherited mutations. Identifying germline risk at the point of cancer diagnosis enables cascade testing that can prevent cancer in at-risk family members through enhanced surveillance and risk-reducing interventions.

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Economics Favor Early Profiling

Sequential single-gene testing costs more and takes longer than upfront comprehensive panels. One test at diagnosis replaces months of trial-and-error prescribing, reducing total cost of care while improving outcomes.

Four Pillars of Oncology Genomics

Comprehensive cancer genomics integrates somatic, germline, pharmacogenomic, and longitudinal monitoring into a unified diagnostic framework.

01
Somatic

Tumor Profiling

Comprehensive genomic profiling of the tumor to identify actionable mutations, gene fusions, and biomarkers that guide targeted therapy selection.

  • Actionable mutation identification
  • Targeted therapy matching
  • TMB & MSI assessment
  • Clinical trial eligibility
  • Resistance mechanism detection
02
Germline

Cancer Predisposition

Hereditary cancer syndrome testing identifies inherited mutations that inform surgical decisions, surveillance strategies, and family cascade testing.

  • BRCA1/2 and PALB2
  • Lynch syndrome (MMR genes)
  • Li-Fraumeni (TP53)
  • Cascade family testing
  • Risk-reducing intervention planning
03
PGx

Pharmacogenomics

Predict how patients metabolize chemotherapy agents to optimize dosing, avoid severe toxicity, and select regimens most likely to be effective and tolerable.

  • DPYD & fluoropyrimidine toxicity
  • UGT1A1 & irinotecan metabolism
  • TPMT/NUDT15 & thiopurines
  • Dose optimization
  • Adverse event prevention
04
Longitudinal

Liquid Biopsy

Circulating tumor DNA monitoring enables real-time disease tracking without invasive tissue biopsies, detecting recurrence and resistance earlier than imaging.

  • ctDNA monitoring
  • Minimal residual disease (MRD)
  • Treatment response assessment
  • Early recurrence detection
  • Resistance evolution tracking

The Genomic Oncology Evidence Base

The data is unambiguous: comprehensive genomic profiling at diagnosis changes care, saves lives, and reduces cost.

50%+
Actionable Alterations
Of cancers harbor genomic alterations matched to approved or investigational targeted therapies
5-10%
Hereditary Cancer
Of all cancers are attributable to inherited germline mutations in cancer predisposition genes
20%+
Toxicity Predicted
Of chemotherapy regimens have pharmacogenomic markers that predict severe or life-threatening toxicity
73%
Management Changed
Of patients with actionable findings have their treatment plan modified based on genomic results
30%
Survival Improvement
Median improvement in progression-free survival when patients receive genomically-matched therapy vs. unmatched
2x
Response Rate
Higher objective response rates observed in patients treated with biomarker-matched therapies

CarePathway: Oncology

A bundled, value-based approach that integrates genomic testing into cancer care from the moment of diagnosis through treatment selection and family risk management.

1

Referral & Intake

Oncology referral triggers automatic genomic pathway enrollment. Clinical criteria route to appropriate testing tier.

2

Comprehensive Profiling

Somatic tumor profiling, germline panel, and PGx testing ordered as a coordinated bundle at diagnosis.

3

Precision Therapy

Results integrated into tumor board review. Targeted therapy selection based on molecular profile, not empiric protocol.

4

Monitoring & Cascade

Liquid biopsy for longitudinal monitoring. Germline findings trigger cascade testing to protect at-risk family members.

Bundled Episode Payment

All testing, counseling, and interpretation bundled into a single care episode with a defined cost -- replacing fragmented, sequential single-gene authorizations.

Measurable Outcomes

Diagnostic yield, time-to-targeted-therapy, toxicity avoidance rate, and cascade testing uptake -- all tracked as program KPIs with auditable endpoints.

Total Cost Reduction

Upfront comprehensive profiling eliminates sequential testing, reduces trial-and-error prescribing, prevents avoidable toxicity, and accelerates time to effective therapy.